光热治疗
药物输送
纳米片
阿霉素
材料科学
纳米技术
纳米材料
聚乙二醇
体内
PEG比率
药品
生物相容性
生物安全
癌症治疗
纳米载体
生物医学工程
化学
药理学
癌症
化疗
医学
生物化学
生物
有机化学
外科
生物技术
经济
病理
冶金
内科学
财务
作者
Xiaoli Yuan,Ying Zhu,Shasha Li,Yiqun Wu,Zhongshi Wang,Rui Gao,Shiyao Luo,Juan Shen,Jun Wu,Liang Ge
标识
DOI:10.1186/s12951-022-01374-0
摘要
Two-dimensional (2D) Titanium nanosheets (Ti NSs) have shown many excellent properties, such as nontoxicity, satisfactory photothermal conversion efficacy, etc. However, the biomedical applications of Ti NSs have not been intensively investigated. Herein, we synthesized a multifunctional Ti NS drug delivery system modified with polydopamine/polyethylene glycol (Ti@PDA-PEG) and applied simultaneously for photothermal therapy and chemotherapy. Doxorubicin (DOX) was utilized as a model drug. Ti@PDA-PEG NS shows an ultrahigh antitumor drug DOX loading (Ti@PDA-PEG-DOX). The prepared Ti@PDA-PEG-DOX NS as robust drug delivery system demonstrates great stability and excellent multi-response drug-release capabilities, including pH-responsive and near-infrared -responsive behavior and obviously high photothermal efficiency. Both in vitro and in vivo experimental results have shown high biosafety and outstanding antitumor effects. Therefore, this work exhibits the enormous potential of a multifunctional platform in the treatment of tumors and may stimulate interest in the exploration of other new 2D nanomaterials for biomedical applications.
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