催化亚单位
癌症研究
蛋白激酶A
癌症
激酶
DNA
生物
蛋白质亚单位
医学
生物信息学
细胞生物学
基因
遗传学
作者
Emanuela Dylgjeri,Karen E. Knudsen
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2021-12-10
卷期号:82 (4): 523-533
被引量:27
标识
DOI:10.1158/0008-5472.can-21-1756
摘要
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression and activity are frequently deregulated in multiple hematologic and solid tumors and have been tightly linked to poor outcome. Given the potentially influential role of DNA-PKcs in cancer development and progression, therapeutic targeting of this kinase is being tested in preclinical and clinical settings. This review summarizes the latest advances in the field, providing a comprehensive discussion of DNA-PKcs functions in cancer and an update on the clinical assessment of DNA-PK inhibitors in cancer therapy.
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