孟德尔随机化
医学
内科学
2型糖尿病
糖化血红素
观察研究
结直肠癌
高胰岛素血症
糖尿病
因果关系（物理学）
血糖性
胰岛素
内分泌学
癌症
肿瘤科
胰岛素抵抗
基因型
生物
遗传学
遗传变异
基因
物理
量子力学
作者
Neil Murphy,Mingyang Song,Nikos Papadimitriou,Robert Carreras‐Torres,Claudia Langenberg,Richard M. Martin,Konstantinos K. Tsilidis,Inês Barroso,Ji Chen,Timothy M. Frayling,Caroline J. Bull,Emma E. Vincent,Michelle Cotterchio,Stephen B. Gruber,Rish K. Pai,Polly A. Newcomb,Aurora Perez‐Cornago,Fränzel J.B. van Duijnhoven,Bethany Van Guelpen,Pavel Vodička
摘要
Glycemic traits-such as hyperinsulinemia, hyperglycemia, and type 2 diabetes-have been associated with higher colorectal cancer risk in observational studies; however, causality of these associations is uncertain. We used Mendelian randomization (MR) to estimate the causal effects of fasting insulin, 2-hour glucose, fasting glucose, glycated hemoglobin (HbA1c), and type 2 diabetes with colorectal cancer.
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(2025-6-4)
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