Improvement of target coverage using automated non-coplanar volumetric modulated arc therapy planning in stereotactic radiotherapy for cervical metastatic spinal tumors

医学 核医学 放射治疗 剂量学 放射治疗计划 放射外科 放射科 外科
作者
Shingo Ohira,Toshiki Ikawa,Shoki Inui,Naoyuki Kanayama,Yoshihiro Ueda,Michihiko Miyazaki,Teiji Nishio,Masahiko Koizumi,Koji Konishi
出处
期刊:Medical Dosimetry [Elsevier]
卷期号:48 (3): 197-201 被引量:2
标识
DOI:10.1016/j.meddos.2023.04.001
摘要

This study aimed to compare dosimetric parameters for targets and organs at risk (OARs) between volumetric modulated arc therapy (VMAT) and automated VMAT (HyperArc, HA) plans in stereotactic radiotherapy for patients with cervical metastatic spine tumors. VMAT plans were generated for 11 metastases using the simultaneous integrated boost technique to deliver 35 to 40 and 20 to 25 Gy for high dose and elective dose planning target volume (PTVHD and PTVED), respectively. The HA plans were retrospectively generated using 1 coplanar and 2 noncoplanar arcs. Subsequently, the doses to the targets and OARs were compared. The HA plans provided significantly higher (p < 0.05) Dmin (77.4 ± 13.1%), D99% (89.3 ± 8.9%), and D98% (92.5 ± 7.7%) for gross tumor volume (GTV) than those of the VMAT plans (73.4 ± 12.2%, 84.2 ± 9.6 and 87.3 ± 8.8% for Dmin, D99% and D98%, respectively). In addition, D99% and D98% for PTVHD were significantly higher in the HA plans, whereas dosimetric parameters were comparable between the HA and VMAT plans for PTVED. The Dmax values for the brachial plexus, esophagus, and spinal cord were comparable, and no significant difference was observed in the Dmean for the larynx, pharyngeal constrictor, thyroid, parotid grand (left and right), and Submandibular gland (left and right). The HA plans provided significantly higher target coverage of GTV and PTVHD, with a comparable dose for OARs with VMAT plans. The results of this study may contribute to the improvement of local control in clinical practice.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
乖乖完成签到,获得积分10
1秒前
布丁发布了新的文献求助10
1秒前
2秒前
NexusExplorer应助古德猫宁采纳,获得10
2秒前
英俊的铭应助ChenCC采纳,获得10
2秒前
整齐向卉发布了新的文献求助10
2秒前
wh雨发布了新的文献求助10
3秒前
万能图书馆应助sidegate采纳,获得10
3秒前
4秒前
机械腾发布了新的文献求助10
4秒前
daisies完成签到,获得积分10
4秒前
NexusExplorer应助黑米粥采纳,获得10
5秒前
可乐要加冰完成签到,获得积分10
5秒前
麦片粥发布了新的文献求助10
5秒前
研友_ng9Jq8完成签到,获得积分10
7秒前
hedgehog完成签到,获得积分10
7秒前
整齐向卉完成签到,获得积分10
7秒前
8秒前
8秒前
老年陈皮发布了新的文献求助10
8秒前
NexusExplorer应助夙与采纳,获得10
10秒前
黄毛虎发布了新的文献求助10
10秒前
paparazzi221应助ding采纳,获得50
10秒前
Vert完成签到,获得积分20
11秒前
hedgehog发布了新的文献求助10
12秒前
12秒前
赘婿应助陶醉水云采纳,获得10
13秒前
13秒前
damieob发布了新的文献求助10
14秒前
老年陈皮完成签到,获得积分20
15秒前
满意静丹完成签到,获得积分10
15秒前
15秒前
15秒前
大个应助宗宗采纳,获得10
15秒前
伶俐板栗完成签到,获得积分10
16秒前
白vv应助抄手爱吃皮采纳,获得10
16秒前
英俊的铭应助lang采纳,获得10
16秒前
李y梅子完成签到 ,获得积分10
16秒前
亮亮完成签到,获得积分10
16秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Femoral insertion of the ACL. Radiographic quadrant method 1000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3194220
求助须知:如何正确求助?哪些是违规求助? 2843167
关于积分的说明 8043462
捐赠科研通 2507648
什么是DOI,文献DOI怎么找? 1339979
科研通“疑难数据库(出版商)”最低求助积分说明 638854
邀请新用户注册赠送积分活动 607696