周细胞
神经血管束
血管生成
血脑屏障
基底层
神经保护
医学
神经科学
生物
病理
中枢神经系统
内皮干细胞
癌症研究
体外
生物化学
超微结构
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:2023-05-16
卷期号:100 (20): 970-977
标识
DOI:10.1212/wnl.0000000000207379
摘要
Pericytes are fundamental components of the neurovascular unit (NVU). They interact with endothelial cells, basal lamina (basement membrane), and glial cells and have a critical role in maintenance of blood-brain barrier (BBB) stability, local control of capillary blood flow, angiogenesis, and immune responses. Pericytes may also function as stem cells with potential to differentiate to into smooth muscle, glial cells, or neurons. A wide range on neurologic disorders, including vascular disorders, neurodegenerative disorders such as Alzheimer disease (AD), traumatic injury, and multiple sclerosis (MS) are associated with changes in pericyte structure and function affecting the NVU. Dysfunctional pericyte signaling may be a potential biomarker of NVU pathology and provides therapeutic targets for neuroprotection. The functions of pericytes and their role in neurologic disorders have been the subject of several comprehensive reviews.1-13
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