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Outcomes in elective compared to non-elective fetal reduction by radiofrequency ablation in monochorionic multifetal pregnancies

医学 怀孕 回顾性队列研究 射频消融术 产科 胎儿 妊娠期 活产 队列 烧蚀 外科 内科学 遗传学 生物
作者
Rachel Meislin,Joanne Stone,R. Lookstein,Guillaume Stoffels,Andrei Rebarber,Nathan S. Fox,Luciana Vieira
出处
期刊:Fetal Diagnosis and Therapy [Karger Publishers]
卷期号:50 (2): 121-127
标识
DOI:10.1159/000530155
摘要

Higher order fetal gestation is associated with adverse pregnancy outcomes, and monochorionic (MC) pregnancies have unique complications. Multifetal pregnancy reduction (MPR) by radiofrequency ablation (RFA) may be used to optimize the outcomes of a single fetus. The purpose of this study was to determine whether pregnancy outcomes differ for elective reduction compared to reduction for medically complicated MC multifetal pregnancies.This was a retrospective cohort of patients with MC twins and higher order multiples who underwent MPR via RFA at a single institution between 2008 and 2021. Patients undergoing elective reduction were compared to patients undergoing reduction due to a complication of MC pregnancy. Pregnancy outcomes were evaluated.Forty-eight patients who underwent RFA reduction between 2008 and 2021 were included in the analysis. Sixteen patients (33.3%) underwent elective RFA for MPR, and 32 (66.7%) underwent an RFA procedure for a complicated pregnancy. All pregnancies with RFA performed for elective indication had a continuing pregnancy (live birth rate 100%). There were no reported pregnancy losses within 4 weeks of the procedure when performed for a solely elective indication (n = 0) compared to 6.3% of complicated multifetal pregnancy (n = 2; 6.3%) (p = 0.001).In this retrospective cohort study, elective reduction of MC twins using RFA was associated with no cases of fetal loss or PPROM within 4 weeks of the procedure and a 100% live birth rate.
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