Advanced Nanostrategies for Biomolecule Delivery in Plant Disease Management

Sustainable plant disease management has long been a major issue in agriculture since the excessive reliance on broad-spectrum pesticides exacerbates chemical resistance, presenting environmental and health hazards. Taking cues from nature's intricate defense mechanisms, scientists are exploiting bioactive agents involved in plant–pathogen/pest interactions to develop novel strategies to combat diseases. Embracing biomolecules in agriculture offers an ecofriendly alternative to chemical pesticides. However, traditional delivery methods for biomolecules often suffer from low utilization rates and low field stability, diminishing the overall effectiveness of active compounds. The advent of nanotechnology has facilitated the design of novel delivery systems for biomolecular cargos, further enhancing their capacity to adhere to plant surfaces and make disease control strategies effective. Tailored depending upon the extent of infection and type of plant species, innovative nanoparticle strategies maximize the effectiveness of delivery by modifying the size, surface characteristics, and adhesion capacity of the particles to suit particular requirements. This review examines how the various biological factors involved in innate plant defenses can be exploited, as well as the potential of various nanocarriers in biomolecule delivery for plant disease management.