Association of precuneus Aβ burden with default mode network function

Abstract INTRODUCTION It remains unclear whether the local amyloid‐beta (Aβ) burden in key regions within the default mode network (DMN) affects network and cognitive functions. METHODS Participants included 1002 individuals from the Chinese Preclinical Alzheimer's Disease Study cohort who underwent 18F‐florbetapir positron emission tomography resting‐state functional magnetic resonance imaging scanning and neuropsychological tests. The correlations between precuneus (PRC) Aβ burden, DMN function, and cognitive function were investigated. RESULTS In individuals with high PRC Aβ burden, there is a bidirectional relationship between DMN local function or functional connectivity and PRC Aβ deposition across various cognitive states, which is also linked to cognitive function. Even below the PRC Aβ threshold, DMN function remains related to PRC Aβ deposition and cognitive performance. DISCUSSION The findings reveal the critical role of PRC Aβ deposition in disrupting neural networks associated with cognitive decline and the necessity of early detection and monitoring of PRC Aβ deposition. Highlights Precuneus (PRC) Aβ burden impacts DMN function in different cognitive stages. High PRC Aβ burden is linked to early neural compensation and subsequent dysfunction. Low PRC Aβ burden correlates with neural changes before significant Aβ accumulation. Changes in DMN function and connectivity provide insights into AD progression. Early detection of regional Aβ burden can help monitor the risk of cognitive decline.