串扰
肠道菌群
代谢综合征
生物信息学
代谢途径
胃肠道
免疫系统
生物
医学
计算生物学
新陈代谢
免疫学
内分泌学
生物化学
肥胖
物理
光学
作者
Penghui Nie,Liehai Hu,Xiaoyan Feng,Hengyi Xu
出处
期刊:Nutrition Reviews
[Oxford University Press]
日期:2024-11-06
标识
DOI:10.1093/nutrit/nuae157
摘要
Abstract The microbiota in humans consists of trillions of microorganisms that are involved in the regulation of the gastrointestinal tract and immune and metabolic homeostasis. The gut microbiota (GM) has a prominent impact on the pathogenesis of metabolic syndrome (MetS). This process is reciprocal, constituting a crosstalk process between the GM and MetS. In this review, GM directly or indirectly inducing MetS via the host–microbial metabolic axis has been systematically reviewed. Additionally, the specifically altered GM in MetS are detailed in this review. Moreover, short-chain fatty acids (SCFAs), as unique gut microbial metabolites, have a remarkable effect on MetS, and the role of SCFAs in MetS-related diseases is highlighted to supplement the gaps in this area. Finally, the existing therapeutics are outlined, and the superiority and shortcomings of different therapeutic approaches are discussed, in hopes that this review can contribute to the development of potential treatment strategies.
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