The widespread use of case method around the world, coupled with conflicting evidence about its effectiveness compared to the traditional lecture method, motivated this study. We meta-analyzed 22 investigations that report 86 effect sizes aggregated in two types of outcomes: cognitive (i.e., knowledge and skills), and affective (i.e., motivation and attitudes). For case method, meta-analytic results were significant for cognitive outcomes, but not for affective outcomes. Furthermore, the case method demonstrated a higher effect than lecture method in the teaching of cognitive outcomes. We also evaluate the effect of two moderators on these relationships, reporting significant effects in undergraduate students and non-significant moderation in cultural values. We discuss and interpret these findings considering different learning theories and propose both theoretical and practical implications.