New domestic intraocular lenses. Resistance to biodegradation processes in comparison with foreign analogues

Relevance. Due to the high demand for import substitution, the prospect of assessing the long-term results of implantation of domestic models of intraocular lenses (IOL) will determine their place among a wide range of models offered by modern manufacturers in our country and abroad. Purpose. To evaluate, in an in-vitro experiment on aging modeling, the resistance of new domestic IOLs to biodegradation processes in comparison with foreign analogues. Material and methods. 3 IOLs of the following models were taken: domestic IOLs made of hydrophobic acrylic: Citrine, Citrine TT, Citrine Action; domestic hydrophilic acrylic Aquamarine IOLs. Foreign hydrophobic acrylic IOLs of the AcrySof SN60AT model and hydrophilic IOLs of Rumex rAqua-4 were taken as reference. Before the experiment, the optical parameters of the studied IOLs were measured: optical power, modulation transmission function (MTF), Strel number. The induction of glistening was carried out as follows: IOLs immersed in a BSS solution were placed in an oven foR²4 hours with a temperature of 45 °С. Further, cooling was carried out to 37 °С foR².5 hours. IOL photofixation was performed at 80-fold magnification with an assessment of the degree of glistening. Optical parameters were repeatedly measured. Results. Glistening was not detected in Aquamarine IOL and Rumex rAqua-4. The 2nd and higher degree of glistening was not detected in any model of hydrophobic IOLs. The optical strength of all the studied IOLs changed in the range from 0.23 to 1.6%. MTF changes ranged from 0 to 3.7%. The number of Strel has changed in the range from 0 to 8.5%. The absence of glistening in hydrophilic IOLs can be explained by a more uniform distribution of water in the material. Differences in the degree of glistening in hydrophobic IOL models may be due to differences in production methods. The revealed changes in optical parameters are insignificant and do not exceed the limits of state standards. Conclusion. Domestic IOLs represent a worthy competition to foreign models, as they have advantages in terms of the availability of high-quality IOLs of aspherical design and a reduced degree of susceptibility to glistening. Key words: domestic intraocular lenses, hydrophobic acrylic, hydrophilic acrylic, glistening, inducing glistening, modeling of IOL aging