1Department of Gastroenterology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China; 2Department of Gastroenterology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China; 3Department of Pharmacology, College of Pharmacy, Naval Medical University, Shanghai, 200433, China. Correspondence: Yu Liu, MD. E-mail: [email protected]. *Jin-Hui Yi and Jin-Jie Xu contributed equally to this work.