化学
苯乙烯
表面改性
组合化学
有机化学
基质(水族馆)
氧化还原
羧酸
聚合物
共聚物
海洋学
地质学
物理化学
作者
Kimberly Benedetti Vega,André Luiz Carvalho de Oliveira,Burkhard König,Márcio W. Paixão
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-01-22
卷期号:26 (4): 860-865
被引量:6
标识
DOI:10.1021/acs.orglett.3c04015
摘要
β-Amidated carboxylic acids, or succinamic acid derivatives, constitute a valuable chemical scaffold with broad applications in pharmaceuticals, agrochemicals, and polymer sciences. Herein, we report a redox-neutral multicomponent reaction for the synthesis of succinamic acid derivatives in good yields. This protocol involves styrene, CO2 and 1,4-carbamoyl-dihydropyridine as radical precursors. The method exhibits a broad substrate scope under mild reaction conditions, including late-stage functionalization. Moreover, by employing 13CO2, the method enables the synthesis of labeled 1,2-dicarboxylic compounds.
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