自愈水凝胶
材料科学
纳米技术
多孔性
免疫系统
药物输送
复合材料
生物
高分子化学
免疫学
作者
Adrienne E. Widener,Abilene Roberts,Edward A. Phelps
标识
DOI:10.1002/adhm.202303005
摘要
Abstract This review aims to understand the current progress in immune‐instructive granular hydrogels and identify the key features used as immunomodulatory strategies. Published work is systematically reviewed and relevant information about granular hydrogels used throughout these studies is collected. The base polymer, microgel generation technique, polymer crosslinking chemistry, particle size and shape, annealing strategy, granular hydrogel stiffness, pore size and void space, degradability, biomolecule presentation, and drug release are cataloged for each work. Several granular hydrogel parameters used for immune modulation: porosity, architecture, bioactivity, drug release, cell delivery, and modularity, are identified. The authors found in this review that porosity is the most significant factor influencing the innate immune response to granular hydrogels, while incorporated bioactivity is more significant in influencing adaptive immune responses. Here, the authors' findings and summarized results from each section are presented and suggestions are made for future studies to better understand the benefits of using immune‐instructive granular hydrogels.
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