长双歧杆菌
鼠李糖乳杆菌
益生菌
伤口愈合
植物乳杆菌
医学
微生物学
双歧杆菌
免疫学
生物
乳酸菌
细菌
发酵
食品科学
乳酸
遗传学
作者
Dimitrios Panagiotou,Eirini Filidou,Maria Gaitanidou,Gesthimani Tarapatzi,Michail Spathakis,Leonidas Kandilogiannakis,George Stavrou,Konstantinos Arvanitidis,Joulia K. Tsetis,Persefoni Gionga,Anne D. Shrewsbury,Vangelis G. Manolopoulos,Dora Kapoukranidou,Konstantinos Lasithiotakis,George Kolios,Katerina Kotzampassi
出处
期刊:Nutrients
[MDPI AG]
日期:2023-04-10
卷期号:15 (8): 1822-1822
被引量:2
摘要
The probiotics Lactiplantibacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58 and Bifidobacterium longum UBBL-64 seem to promote wound healing when applied topically. Our aim was to investigate their effect on the mRNA expression of pro-inflammatory, healing and angiogenetic factors during the healing process of a standardized excisional wound model in rats. Rats subjected to six dorsal skin wounds were allocated to Control; L. plantarum; combined formula of L. rhamnosus plus B. longum; L. rhamnosus; and B. longum treatments, applied every two days, along with tissue collection. The pro-inflammatory, wound-healing, and angiogenetic factors of mRNA expression were assessed by qRT-PCR. We found that L. plantarum exerts a strong anti-inflammatory effect in relation to L. rhamnosus-B. longum, given alone or in combination; the combined regime of L. rhamnosus-B. longum, works better, greatly promoting the expression of healing and angiogenic factors than L. plantarum. When separately tested, L. rhamnosus was found to work better than B. longum in promoting the expression of healing factors, while B. longum seems stronger than L. rhamnosus in the expression of angiogenic factors. We, therefore, suggest that an ideal probiotic treatment should definitively contain more than one probiotic strain to speed up all three healing phases.
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