Single‐Site SnOCu Pairs with Interfacial Electron Transfer Effect for Enhanced Electrochemical Catalysis and Sensing

Abstract As advanced electrochemical catalysts, single‐atom catalysts have made great progress in the field of catalysis and sensing due to their high atomic utilization efficiency and excellent catalytic performance. Herein, stannum‐doped copper oxide (CuOSn 1 ) nanosheets with single‐site SnOCu pairs as active sites are synthesized as electrocatalysts for biological molecule detection. Compared with CuO‐based electrochemical sensors, the CuOSn 1 ‐based electrochemical sensors have improved detection sensitivity with a rapid electrochemical response. Theoretical calculation reveals that the single‐site SnOCu pairs induced interfacial electronic transfer effect can strengthen hydroxy adsorption and thus reduce the energy barrier of the biological molecule oxidation process. As a concept application, electrochemical detection of dopamine and uric acid molecules is achieved, exhibiting satisfactory sensitivity and selectivity. This work demonstrates the advantages of single‐site SnOCu pairs in electrochemical catalysis and sensing, which provides theoretical guidance for understanding the structure‐activity relationship for sensitive electrochemical sensing.