Comparison of the Correlation Between Coagulation Indices and Rivaroxaban Concentrations

拜瑞妥 显色的 部分凝血活酶时间 医学 凝血酶原时间 药代动力学 高效液相色谱法 药效学 色谱法 凝结 药理学 内科学 化学 华法林 心房颤动
作者
Tingting Wu,Shuyi Wu,Meijuan Li,Jinhua Zhang
出处
期刊:Annals of Pharmacotherapy [SAGE]
卷期号:58 (1): 28-36 被引量:2
标识
DOI:10.1177/10600280231158929
摘要

Background: Rivaroxaban has predictable pharmacokinetics and pharmacodynamics. However, monitoring rivaroxaban concentrations should be provided for special patients with hepatic insufficiency, high bleeding risk, and high thrombotic risk. Objective: This study aimed to correlate chromogenic anti-Xa assay, prothrombin time (PT), activated partial thromboplastin time (APTT), thromboelastogram reaction time (TEG R-time), and rivaroxaban concentration measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) (MS-Riva). Methods: Peripheral venous blood was collected from recruited patients 30 minutes before and 2 to 4 hours after drug administration. High-performance liquid chromatography-tandem mass spectrometry and chromogenic anti-Xa assay measured rivaroxaban concentration. Different assays were compared by Pearson correlation coefficient and Bland-Altman analysis. Results: A total of 104 patients with 191 plasma were included in the study. Overall analysis shows that chromogenic anti-Xa assay, PT, APTT, and TEG R-time strongly correlated with MS-Riva ( r = 0.986; r = 0.884; r = 0.741; r = 0.739; P < 0.001). Rivaroxaban peak concentration detected by HPLC-MS/MS (MS-peak) showed a very strong correlation with the chromogenic anti-Xa assay ( r = 0.977, P < 0.001) and moderate correlation with PT, APTT, and TEG R-time ( r = 0.670; r = 0.571; r = 0.481, P < 0.001). Rivaroxaban trough concentration detected by HPLC-MS/MS (MS-trough) correlated strongly with the chromogenic anti-Xa assay ( r = 0.884, P < 0.001), weakly with APTT ( r = 0.313; P = 0.043), and not significantly with PT and TEG R-time ( P = 0.140; P = 0.341). Conclusion and Relevance: High-performance liquid chromatography-tandem mass spectrometry/MS is the preferred choice for monitoring peak and tough concentrations, followed by anti-Xa, while PT is only suitable for peak concentrations. This study can help the clinicians to better adjust the medication regimen and reduce the risk of recurrence of thrombosis as well as the risk of bleeding.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zym发布了新的文献求助10
1秒前
3秒前
范浩然完成签到 ,获得积分10
3秒前
5秒前
情怀应助研友_nv2r4n采纳,获得10
5秒前
腼腆的灰狼完成签到,获得积分20
6秒前
6秒前
7秒前
33应助清新的静枫采纳,获得10
7秒前
小菜鸟完成签到,获得积分10
8秒前
科研通AI2S应助小龟别乱跑采纳,获得10
10秒前
ZWGS发布了新的文献求助10
11秒前
我是老大应助幽默的百川采纳,获得10
11秒前
11秒前
胖胖橘发布了新的文献求助10
12秒前
12秒前
土豆你个西红柿完成签到 ,获得积分10
15秒前
anlikek发布了新的文献求助10
16秒前
16秒前
Orange应助ZWGS采纳,获得10
19秒前
INITIAL完成签到,获得积分10
19秒前
19秒前
19秒前
19秒前
19秒前
zho应助信仰采纳,获得10
20秒前
20秒前
仁者无惧完成签到 ,获得积分10
21秒前
songvv给songvv的求助进行了留言
23秒前
吃花生酱的猫应助麦克尔采纳,获得20
23秒前
anlikek完成签到,获得积分10
24秒前
24秒前
疯少发布了新的文献求助10
24秒前
英姑应助zym采纳,获得10
25秒前
c程序语言发布了新的文献求助10
25秒前
25秒前
Lucas应助白云采纳,获得10
26秒前
娃哈哈完成签到 ,获得积分10
27秒前
27秒前
畅快幻柏发布了新的文献求助10
28秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 830
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3247606
求助须知:如何正确求助?哪些是违规求助? 2890926
关于积分的说明 8265247
捐赠科研通 2559191
什么是DOI,文献DOI怎么找? 1387904
科研通“疑难数据库(出版商)”最低求助积分说明 650658
邀请新用户注册赠送积分活动 627495