RBP4-based Multimarker Score: A Prognostic Tool for Adverse Cardiovascular Events in Acute Coronary Syndrome Patients

内科学 医学 急性冠脉综合征 四分位间距 心脏病学 射血分数 肾功能 维加维斯 利钠肽 心力衰竭 胰岛素抵抗 心肌梗塞 肥胖 脂肪因子
作者
Bingqi Ye,Qian Zhao,Jiahua Fan,Xiaomei Li,Chunfang Shan,Fen Liu,Ning Song,Jiajun Zhu,Min Xia,Yan Liu,Yi‐Ning Yang
出处
期刊:The Journal of Clinical Endocrinology and Metabolism [Oxford University Press]
卷期号:108 (12): 3111-3121
标识
DOI:10.1210/clinem/dgad389
摘要

Retinol binding protein 4 (RBP4) has been implicated in the progression of cardiovascular diseases. However, its association with major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS) remains obscure.Here, we examined the prognostic value of baseline RBP4 and its derived multimarker score for MACEs in ACS patients.A total of 826 patients with ACS were consecutively recruited from the department of cardiology and prospectively followed up for a median of 1.95 years (interquartile range, 1.02-3.25 years). Plasma RBP4 was measured using enzyme-linked immunosorbent assay. Adjusted associations between RBP4 and its derived multimarker score (1 point was assigned when RBP4 ≥ 38.18μg/mL, left ventricular ejection fraction [LVEF] ≤ 55%, N-terminal pro-B-type natriuretic peptide [NT-proBNP] ≥ 450 ng/L, estimated glomerular filtration rate [eGFR] ≤ 90 mL/min/1.73 m2, and age ≥60) with MACEs were analyzed.In total, 269 ACS patients (32.57%) experienced MACEs. When patients were grouped by multimarker score (0-1, n = 315; 2-3, n = 406; 4-5, n = 105), there was a significant graded association between RBP4-based multimarker score and risk of MACEs (intermediate score (2-3): HRadj: 1.80; 95% CI, 1.34-2.41; high score (4-5): HRadj: 3.26; 95% CI, 2.21-4.81) and its components (P < .05 for each). Moreover, the prognostic and discriminative value of the RBP4-derived multimarker score remained robust in ACS patients with various high-risk anatomical or clinical characteristics.The RBP4-derived 5-item score serves as a useful risk stratification and decision support for secondary prevention in patients with ACS.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
上官若男应助俏皮的白柏采纳,获得10
2秒前
量子星尘发布了新的文献求助10
5秒前
充电宝应助Jay采纳,获得10
7秒前
orixero应助qp采纳,获得10
9秒前
醍醐不醒完成签到 ,获得积分10
10秒前
gaberella完成签到,获得积分10
11秒前
沐晴发布了新的文献求助150
12秒前
LANER完成签到 ,获得积分10
12秒前
13秒前
xmk完成签到 ,获得积分10
14秒前
cindywu完成签到,获得积分10
14秒前
ccc发布了新的文献求助10
14秒前
16秒前
17秒前
18秒前
18秒前
Star1983发布了新的文献求助10
22秒前
22秒前
坚定馒头发布了新的文献求助10
22秒前
项绝义发布了新的文献求助200
23秒前
Supreme发布了新的文献求助10
25秒前
26秒前
26秒前
28秒前
28秒前
28秒前
30秒前
青柠发布了新的文献求助10
30秒前
nannan发布了新的文献求助10
31秒前
32秒前
32秒前
32秒前
TKTK发布了新的文献求助30
32秒前
Stroeve发布了新的文献求助20
33秒前
37秒前
38秒前
39秒前
41秒前
lelelele发布了新的文献求助10
41秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988920
求助须知:如何正确求助?哪些是违规求助? 3531290
关于积分的说明 11253247
捐赠科研通 3269903
什么是DOI,文献DOI怎么找? 1804830
邀请新用户注册赠送积分活动 882027
科研通“疑难数据库(出版商)”最低求助积分说明 809052