A Comprehensive Review on the Identification of Blood-Based Biomarkers for Alzheimer’s Disease Detection Through Computational Approaches

鉴定(生物学) 疾病 医学 计算生物学 计算机科学 生物 病理 植物
作者
Anirban Maitra,Pushpendra Kumar,M. K. Jha
出处
期刊:Lecture notes in networks and systems 卷期号:: 435-449
标识
DOI:10.1007/978-981-99-2100-3_34
摘要

Alzheimer’s disease (AD) is a neurodegenerative disorder and most common form of dementia. AD is characterized by decline in learning and memory. Moreover, due to limited treatment efficacy, early and accurate detection of AD is important. However, this disease is very difficult to diagnose clinically based on the sign and symptoms of the patients. Therefore, cerebrospinal fluid (CSF), magnetic resonance imaging (MRI), computerized tomography (CT), and positron emission tomography (PET)-based measures play a critical role in AD detection. These detection methods are highly inaccessible, invasive, and costly, which limits their use as detecting tools. Therefore, identification of biomarkers in blood samples would be a more practical approach. The identification of these biomarkers opens the door to targeted therapeutic and customized medical approaches as well as aids in understanding the aberrant alterations that lead to disease. The cost, time, and resources required for screening and validation utilizing biological studies or clinical trials are also high. As given the ever growing high throughput data from systematic profiling of thousands of patients for various genome scale omics measurements, including mRNA expression, micro-RNA (miRNA) expression, and DNA sequences, hence there is a need to develop computational methods that help in identifying biomarkers for a given phenotype or diseases. As a result of rapid advancement in bioinformatics analysis, AD-related biomarkers can now be identified in blood as recent work showing promising results. This paper is a systematic review of the published research works, which provides an overview of the progress achieved so far in identification of potential blood biomarkers for AD detection through computational approaches. This study suggests that blood-based biomarkers are easy to detect and also shows higher accuracy in the identification of AD. The possible challenges and key area of application along with the future directions are also discussed in this review paper.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
dyy完成签到,获得积分20
刚刚
1秒前
Zhaojiaokeyan完成签到,获得积分10
1秒前
阿冰完成签到,获得积分10
1秒前
十五完成签到,获得积分10
2秒前
3秒前
3秒前
好啦啦关注了科研通微信公众号
3秒前
Akim应助123采纳,获得10
3秒前
3秒前
刘志成完成签到 ,获得积分10
4秒前
谭谨川完成签到,获得积分10
4秒前
4秒前
伶俐书雁发布了新的文献求助10
4秒前
归尘发布了新的文献求助10
4秒前
bybyby完成签到,获得积分10
4秒前
5秒前
阔达秋翠发布了新的文献求助10
6秒前
aaaaa完成签到,获得积分20
6秒前
梅伊斯发布了新的文献求助10
7秒前
8秒前
枫叶发布了新的文献求助10
8秒前
8秒前
sarach完成签到,获得积分10
8秒前
Ava应助ifanyz采纳,获得10
8秒前
8秒前
网再快点完成签到,获得积分10
8秒前
9秒前
ruby完成签到,获得积分10
9秒前
9秒前
9秒前
10秒前
aaaaa发布了新的文献求助20
10秒前
慕青应助聪明无敌小腚宝采纳,获得10
10秒前
linkman发布了新的文献求助10
11秒前
赘婿应助ren采纳,获得10
11秒前
11秒前
哈哈哈哈哈哈完成签到,获得积分10
11秒前
11秒前
丘比特应助罗C采纳,获得10
12秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974779
求助须知:如何正确求助?哪些是违规求助? 3519193
关于积分的说明 11197417
捐赠科研通 3255311
什么是DOI,文献DOI怎么找? 1797760
邀请新用户注册赠送积分活动 877150
科研通“疑难数据库(出版商)”最低求助积分说明 806187