医学
肺癌
母乳喂养
前瞻性队列研究
后代
队列研究
队列
比例危险模型
癌症
人口学
产科
肿瘤科
内科学
儿科
怀孕
社会学
生物
遗传学
作者
Hang Yin,Yixue Wang,Li Wang,Shijie Zhang,Xiaodong Ling,Tianshu Han,Changhao Sun,Jianqun Ma,Wei Wei,Jinhong Zhu,Xiaoyuan Wang
标识
DOI:10.1097/js9.0000000000001531
摘要
Background: Although previous research has indicated a correlation between smoking and the mortality rate in patients with lung cancer, the impact of early life factors on this relationship remains unclear and requires further investigation. This study aimed to investigate the hypothesis that breastfeeding reduces the risk of lung cancer-related death. Methods The authors conducted a prospective cohort study involving 501 859 participants recruited from the United Kingdom Biobank to explore the potential association between breastfeeding and the risk of lung cancer mortality using a Cox proportional hazards model. Subsequently, the polygenic risk score for lung cancer was calculated to detect interactions between genes and the environment. Results: Over a median follow-up duration of 11.8 years, encompassing a total of 501 859 participants, breastfeeding was found to reduce the risk of lung cancer-related death and the impact of maternal smoking on lung cancer mortality in adult offspring. This association remained consistent after stratification. Furthermore, the influence of maternal smoking and breastfeeding on the risk of lung cancer mortality was significant at a high genetic risk level. Conclusion: Breastfeeding can reduce the risk of lung cancer-related death and the impact of maternal smoking on lung cancer mortality in adult offspring. This correlation has the potential to reduce the probability of lung-cancer-related deaths in subsequent generations.
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