亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Chronic rapid eye movement sleep deprivation aggravates the pathogenesis of Alzheimer’s disease by decreasing brain O-GlcNAc cycling in mice

发病机制 快速眼动睡眠 神经学 疾病 睡眠剥夺 神经科学 医学 阿尔茨海默病 睡眠(系统调用) 眼球运动 心理学 内科学 昼夜节律 计算机科学 操作系统
作者
Dong Yeol Kim,Sang-Min Kim,Inn‐Oc Han
出处
期刊:Journal of Neuroinflammation [Springer Nature]
卷期号:21 (1) 被引量:1
标识
DOI:10.1186/s12974-024-03179-4
摘要

This study investigated the role of O-GlcNAc cycling in Alzheimer's disease-related changes in brain pathophysiology induced by chronic REM sleep deprivation (CSD) in mice. CSD increased amyloid beta (Aβ) and p-Tau accumulation and impaired learning and memory (L/M) function. CSD decreased dendritic length and spine density. CSD also increased the intensity of postsynaptic density protein-95 (PSD-95) staining. All of these Alzheimer's disease (AD) pathogenic changes were effectively reversed through glucosamine (GlcN) treatment by enhancing O-GlcNAcylation. Interestingly, the lelvel of O-GlcNAcylated-Tau (O-Tau) exhibited an opposite trend compared to p-Tau, as it was elevated by CSD and suppressed by GlcN treatment. CSD increased neuroinflammation, as indicated by elevated levels of glial fibrillary acidic protein and IBA-1-positive glial cells in the brain, which were suppressed by GlcN treatment. CSD promoted the phosphorylation of GSK3β and led to an upregulation in the expression of endoplasmic reticulum (ER) stress regulatory proteins and genes. These alterations were effectively suppressed by GlcN treatment. Minocycline not only suppressed neuroinflammation induced by CSD, but it also rescued the decrease in O-GlcNAc levels caused by CSD. Minocycline also reduced AD neuropathy without affecting CSD-induced ER stress. Notably, overexpressing O-GlcNAc transferase in the dentate gyrus region of the mouse brain rescued CSD-induced cognitive dysfunction, neuropathy, neuroinflammation, and ER stress responses. Collectively, our findings reveal that dysregulation of O-GlcNAc cycling underlies CSD-induced AD pathology and demonstrate that restoration of OGlcNAcylation protects against CSD-induced neurodegeneration.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
9秒前
南风发布了新的文献求助20
9秒前
14秒前
Lichun发布了新的文献求助10
20秒前
夜鸢发布了新的文献求助20
36秒前
南风完成签到,获得积分10
1分钟前
英俊的铭应助科研通管家采纳,获得10
1分钟前
Billy应助科研通管家采纳,获得10
1分钟前
xz完成签到 ,获得积分10
1分钟前
ataybabdallah给ataybabdallah的求助进行了留言
2分钟前
不复返的杆完成签到 ,获得积分10
2分钟前
kaginagain完成签到,获得积分10
2分钟前
嗯哼应助更深的蓝采纳,获得30
2分钟前
尔尔完成签到,获得积分20
3分钟前
Billy应助科研通管家采纳,获得10
3分钟前
shangchen发布了新的文献求助10
3分钟前
3分钟前
shangchen完成签到,获得积分10
3分钟前
4分钟前
TXZ06完成签到,获得积分10
4分钟前
尔尔发布了新的文献求助10
4分钟前
4分钟前
caca完成签到,获得积分10
4分钟前
Jasper应助仙布着急采纳,获得10
4分钟前
bukeshuo完成签到,获得积分10
5分钟前
5分钟前
shuqian发布了新的文献求助10
5分钟前
Billy应助科研通管家采纳,获得10
5分钟前
FashionBoy应助科研通管家采纳,获得10
5分钟前
852应助Vivian采纳,获得30
5分钟前
5分钟前
fang发布了新的文献求助10
5分钟前
FashionBoy应助dahai采纳,获得30
5分钟前
5分钟前
fang完成签到,获得积分20
5分钟前
Vivian完成签到,获得积分20
6分钟前
6分钟前
6分钟前
忍冬发布了新的文献求助30
6分钟前
zqq完成签到,获得积分0
6分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196756
求助须知:如何正确求助?哪些是违规求助? 2845422
关于积分的说明 8054102
捐赠科研通 2510046
什么是DOI,文献DOI怎么找? 1342199
科研通“疑难数据库(出版商)”最低求助积分说明 639340
邀请新用户注册赠送积分活动 608633