三氟甲基化
部分
吲哚试验
吲哚
化学
组合化学
魔术(望远镜)
立体化学
有机化学
三氟甲基
烷基
物理
量子力学
作者
Pradeep Kumar,Nikita Goel,Sunita Bhagat
标识
DOI:10.1002/slct.202401371
摘要
Abstract Fluorine being a magic element and Indole being a magic molecule, their cumulative effect has tremendously increased the potential of resulting moiety for drug development. Keeping this in mind, we are describing a comprehensive account on the recent strategies for the synthesis of trifluoromethylated indoles, indoline and oxindoles. In this review we have explored two types of strategies for trifluoromethylation reactions, one involves direct installation of CF 3 group at indole moiety via C−H activation and substitution where as other is by the cyclization reaction of the starting compound containing CF 3 group. The reactions were explored for the substrate scope and mechanism using controlled experiments.
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