苯并呋喃
淀粉样蛋白(真菌学)
化学
靶向治疗
放射化学
癌症研究
医学
立体化学
内科学
癌症
无机化学
作者
Andrew Bender,Emily K. Kirkeby,Donna J. Cross,Satoshi Minoshima,Andrew G. Roberts,Tara E. Mastren
标识
DOI:10.2967/jnumed.124.267482
摘要
Alzheimer disease is a neurodegenerative disorder with limited treatment options. It is characterized by the presence of several biomarkers, including amyloid-β aggregates, which lead to oxidative stress and neuronal decay. Targeted α-therapy (TAT) has been shown to be efficacious against metastatic cancer. TAT takes advantage of tumor-localized α-particle emission to break disease-associated covalent bonds while minimizing radiation dose to healthy tissues due to the short, micrometer-level, distances traveled. We hypothesized that TAT could be used to break covalent bonds within amyloid-β aggregates and facilitate natural plaque clearance mechanisms.
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