CDK9 inhibition by dinaciclib is a therapeutic vulnerability in epithelioid hemangioendothelioma
上皮样血管内皮瘤
医学
病理
免疫组织化学
作者
Ajaybabu V. Pobbati,Ashley Burtscher,Nandini Rajaram Siva,Andrea Hallett,Todd Romigh,Kepeng Che,Bin Zhao,Jesse A. Coker,Nancy Wang,Shaun R. Stauffer,Brian P. Rubin
There are no effective treatment options for patients with aggressive epithelioid hemangioendothelioma (EHE) driven by the TAZ-CAMTA1 (TC) fusion gene. Here, we aimed to understand the regulation of TC using pharmacological tools and identify vulnerabilities that can potentially be exploited for the treatment of EHE.
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