化学
对映选择合成
钌
磷酸
催化作用
组合化学
有机化学
作者
Sidorov An,Yan Zhu,Jiangtao Sun
标识
DOI:10.1021/acs.orglett.4c02135
摘要
The enantioselective carbene insertion into N-H bonds of anilines has been realized by cooperative catalysis of ruthenium complexes and chiral phosphoric acids, providing the expected α-aryl glycines in moderate to good yields with high enantioselectivity. Typically, by slightly modifying the reaction conditions, this approach allows the N-H bond insertion reaction to be effective for both α-aryl and α-alkyl diazoacetates for the first time with high enantioselectivity (up to 96% and 95% ee, respectively).
科研通智能强力驱动
Strongly Powered by AbleSci AI