心理学
亲社会行为
背景(考古学)
发展心理学
心理健康
临床心理学
社会环境
多级模型
纵向研究
社会孤立
萧条(经济学)
精神科
医学
政治学
法学
经济
计算机科学
古生物学
病理
宏观经济学
机器学习
生物
作者
Matias Martínez,Tianying Cai,Beiming Yang,Zexi Zhou,Stewart A. Shankman,Vijay A. Mittal,Claudia M. Haase,Yang Qu
标识
DOI:10.1073/pnas.2321965121
摘要
The transition to adolescence is a critical period for mental health development. Socio-experiential environments play an important role in the emergence of depressive symptoms with some adolescents showing more sensitivity to social contexts than others. Drawing on recent developmental neuroscience advances, we examined whether hippocampal volume amplifies social context effects in the transition to adolescence. We analyzed 2-y longitudinal data from the Adolescent Brain Cognitive Development (ABCD ® ) study in a diverse sample of 11,832 youth (mean age: 9.914 y; range: 8.917 to 11.083 y; 47.8% girls) from 21 sites across the United States. Socio-experiential environments (i.e., family conflict, primary caregiver’s depressive symptoms, parental warmth, peer victimization, and prosocial school environment), hippocampal volume, and a wide range of demographic characteristics were measured at baseline. Youth’s symptoms of major depressive disorder were assessed at both baseline and 2 y later. Multilevel mixed-effects linear regression analyses showed that negative social environments (i.e., family conflict, primary caregiver’s depressive symptoms, and peer victimization) and the absence of positive social environments (i.e., parental warmth and prosocial school environment) predicted greater increases in youth’s depressive symptoms over 2 y. Importantly, left hippocampal volume amplified social context effects such that youth with larger left hippocampal volume experienced greater increases in depressive symptoms in more negative and less positive social environments. Consistent with brain–environment interaction models of mental health, these findings underscore the importance of families, peers, and schools in the development of depression during the transition to adolescence and show how neural structure amplifies social context sensitivity.
科研通智能强力驱动
Strongly Powered by AbleSci AI