抗体
医学
抗体疗法
癌症
免疫学
PD-L1
CTLA-4号机组
免疫疗法
免疫系统
单克隆抗体
T细胞
内科学
作者
Xin Su,Jian Li,Xiao‐Ming Xu,Youbao Ye,C. M. Wang,Guanglong Pang,Wenxiu Liu,Ang Liu,Changchun Zhao,Xiangyong Hao
标识
DOI:10.1186/s12967-024-05552-6
摘要
Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portion of patients. Therefore, it is imperative to develop strategies to enhance the effect of these ICIs. Increasing evidence strongly suggests that the key to this issue is to transform the tumor immune microenvironment from a state of no or low immune infiltration to a state of high immune infiltration and enhance the tumor cell-killing effect of T cells. Therefore, some combination strategies have been proposed and this review appraise a summary of 39 strategies aiming at enhancing the effectiveness of ICIs, which comprise combining 10 clinical approaches and 29 foundational research strategies. Moreover, this review improves the comprehensive understanding of combination therapy with ICIs and inspires novel ideas for tumor immunotherapy.
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