废止
化学
催化作用
组合化学
基质(水族馆)
表面改性
范围(计算机科学)
立体化学
药物化学
有机化学
计算机科学
海洋学
物理化学
程序设计语言
地质学
作者
Mingshuai Zhang,Longkun Chen,Haifeng Sun,Zhuoyuan Liu,Jiuzhong Huang,Fuchao Yu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-10-03
卷期号:25 (40): 7298-7303
被引量:32
标识
DOI:10.1021/acs.orglett.3c02515
摘要
An unprecedented protocol for a Rh(III)-catalyzed [3 + 2] annulation from simple and readily available enaminones and iodonium ylides has been developed. The novel strategy allows for access to a new class of structurally diverse tetrahydro-indolones with high efficiency and a broad substrate scope. In addition, this transformation represents the first example of the selective Rh(III)-catalyzed alkenyl C–H bond functionalization and annulation of enaminones. Finally, the potential applications of this protocol are demonstrated through gram-scale reaction and late-stage modification.
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