多糖
炎症性肠病
炎症体
结肠炎
生物
免疫学
化学
生物化学
炎症
疾病
医学
病理
作者
Shuai Zhang,Mingxu Zhang,Wei Li,Lina Ma,Xinglong Liu,Qiteng Ding,Weimin Yu,Taojing Yu,Chuanbo Ding,Wencong Liu
标识
DOI:10.1016/j.ijbiomac.2023.126799
摘要
Natural plant polysaccharides are macromolecular substances with a wide range of biological activities. They have a wide range of biological activities, especially play an important role in the treatment of inflammatory bowel disease. The molecular weight of polysaccharides, the composition of monosaccharides and the connection of glycosidic bonds will affect the therapeutic effect on inflammatory bowel disease. Traditional Chinese medicine plant polysaccharides and various types of plant polysaccharides reduce the levels of inflammatory cytokines IL-1β, IL-6, IL-8 and IL-17, increase the level of anti-inflammatory factor IL-10, regulate NF-κB signaling pathway, and NLRP3 inflammasome to relieve colitis. At the same time, they can play a protective role by regulating the balance of intestinal flora in mice with colitis and increasing the abundance of probiotics to promote the metabolism of polysaccharide metabolites SCFAs. This review summarizes the research on the treatment of inflammatory bowel disease by many natural plant polysaccharides, and provides a theoretical basis for the later treatment of polysaccharides on inflammatory bowel disease.
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