已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Mitochondria-related lncRNAs: predicting prognosis, tumor microenvironment and treatment response in lung adenocarcinoma

列线图 单变量 比例危险模型 腺癌 肿瘤科 生物 一致性 肺癌 内科学 多元统计 单变量分析 Lasso(编程语言) 生存分析 危险系数 多元分析 癌症 生物信息学 医学 统计 万维网 置信区间 计算机科学 数学
作者
Qianhui Zhou,Jiali Xiong,Yan Gao,Yi Rong,Yuzhu Xu,Quefei Chen,Lin Wang,Ying Chen
出处
期刊:Functional & Integrative Genomics [Springer Science+Business Media]
卷期号:23 (4) 被引量:1
标识
DOI:10.1007/s10142-023-01245-3
摘要

Abstract Lung cancer is the most common type of malignant tumor that affects people in China and even across the globe, as it exhibits the highest rates of morbidity and mortality. Lung adenocarcinoma (LUAD) is a type of lung cancer with a very high incidence. The purpose of this study was to identify potential biomarkers that could be used to forecast the prognosis and improve the existing therapy options for treating LUAD. Clinical and RNA sequencing data of LUAD patients were retrieved from the TCGA database, while the mitochondria-associated gene sets were acquired from the MITOMAP database. Thereafter, Pearson correlation analysis was carried out to screen mitochondria-associated lncRNAs. Furthermore, univariate Cox and Lasso regression analyses were used for the initial screening of the target lncRNAs for prognostic lncRNAs before they could be incorporated into a multivariate Cox Hazard ratio model. Then, the clinical data, concordance index, Kaplan–Meier (K-M) curves, and the clinically-relevant subjects that were approved by the Characteristic Curves (ROC) were employed for assessing the model's predictive value. Additionally, the differences in immune-related functions and biological pathway enrichment between high- and low-risk LUAD groups were examined. Nomograms were developed to anticipate the OS rates of the patients within 1-, 3-, and 5 years, and the differences in drug sensitivity and immunological checkpoints were compared. In this study, 2175 mitochondria-associated lncRNAs were screened. Univariate, multivariate, and Lasso Cox regression analyses were carried out to select 13 lncRNAs with an independent prognostic significance, and a prognostic model was developed. The OS analysis of the established prognostic prediction model revealed significant variations between the high- and low-risk patients. The AUC-ROC values after 1, 3, and 5 years were seen to be 0.746, 0.692, and 0.726, respectively. The results suggested that the prognostic model riskscore could be used as an independent prognostic factor that differed from the other clinical characteristics. After analyzing the findings of the study, it was noted that both the risk groups showed significant differences in their immune functioning, immunological checkpoint genes, and drug sensitivity. The prognosis of patients with LUAD could be accurately and independently predicted using a risk prediction model that included 13 mitochondria-associated lncRNAs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
2秒前
自由念露完成签到 ,获得积分10
3秒前
4秒前
852应助张洁采纳,获得10
5秒前
5秒前
小鲨鱼发布了新的文献求助10
5秒前
怡然枫叶发布了新的文献求助10
5秒前
6秒前
8秒前
诚心千筹完成签到,获得积分10
9秒前
vikoer发布了新的文献求助30
9秒前
AbeleChuang发布了新的文献求助10
9秒前
9秒前
guozizi发布了新的文献求助30
10秒前
10秒前
character577完成签到 ,获得积分10
12秒前
lizibelle发布了新的文献求助10
12秒前
夜雨声烦发布了新的文献求助10
13秒前
13秒前
共享精神应助小鲨鱼采纳,获得10
14秒前
乐乐应助百里如雪采纳,获得10
15秒前
陶醉海燕发布了新的文献求助10
16秒前
bkagyin应助张奕采纳,获得10
16秒前
20秒前
幸福大白发布了新的文献求助10
20秒前
mitty完成签到 ,获得积分10
23秒前
a1207732382发布了新的文献求助50
25秒前
26秒前
米缸完成签到,获得积分10
29秒前
幸福大白发布了新的文献求助10
30秒前
32秒前
帅气的马里奥完成签到 ,获得积分10
39秒前
oh完成签到,获得积分10
41秒前
42秒前
陶醉海燕发布了新的文献求助10
44秒前
激情的代曼完成签到,获得积分10
45秒前
47秒前
研友_VZG7GZ应助tanrui采纳,获得10
47秒前
deway发布了新的文献求助10
47秒前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 1030
A new approach to the extrapolation of accelerated life test data 1000
Indomethacinのヒトにおける経皮吸収 400
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 370
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3994330
求助须知:如何正确求助?哪些是违规求助? 3534764
关于积分的说明 11266452
捐赠科研通 3274665
什么是DOI,文献DOI怎么找? 1806413
邀请新用户注册赠送积分活动 883291
科研通“疑难数据库(出版商)”最低求助积分说明 809749