变构调节
突变体
PI3K/AKT/mTOR通路
基因亚型
化学
癌症研究
药理学
生物
计算生物学
医学
内科学
细胞生物学
生物化学
信号转导
受体
基因
作者
Alison L. Kearney,Neil Vasan
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2023-11-01
卷期号:13 (11): 2313-2315
被引量:1
标识
DOI:10.1158/2159-8290.cd-23-0945
摘要
Summary: This is the first peer-reviewed report of an allosteric, mutant-selective PI3Kα inhibitor, STX-478, that reduces PIK3CA-mutant tumor growth in mice. However, in contrast to the FDA-approved PI3Kα isoform–selective inhibitor alpelisib, STX-478 does not induce hyperglycemia or other metabolic dysfunctions. See related article by Buckbinder et al., p. 2432 (7).
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