单线态氧
化学
光化学
酞菁
光动力疗法
轴对称性
单重态
硅
氧气
原子物理学
有机化学
激发态
量子力学
物理
作者
Gülşah Gümrükçü Köse,Gülnur Keser Karaoğlan
标识
DOI:10.1016/j.chemphys.2022.111737
摘要
This study is based on photodynamic therapy (PDT) and sonophotodynamic therapy (SPDT) which combines photochemical and sonochemical studies, produces high singlet oxygen and provides more effective therapeutic results in the treatment of cancer. For this purpose, a new photosensitizer, naphthoic acid substituted silicon phthalocyanine, is synthesized and characterized by elemental analysis, 1H NMR, FT-IR, MALDI-TOF MS and UV–Vis spectral data and its photophysico-chemical properties are investigated. The singlet oxygen quantum yields that were obtained by photochemical and sono-photochemical methods of the complex, synthesized as a sono-photosensitizer, were calculated and compared by both methods. It was observed that the yield obtained in the sono-photochemical method (ФΔ = 0.74 in DMSO, 0.69 in DMF) was considerably higher than the one obtained in the photochemical method (ФΔ = 0.51 in DMSO, 0.47 in DMF). These results proved that sono-photochemical study remarkably increased the therapeutic effect which is important in cancer treatment.
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