A lipidome landscape of aging in mice

脂质体 单酰甘油脂肪酶 脂类学 糖脂 生物化学 鞘脂 生物 脂质代谢 神经酰胺 酰基转移酶 内大麻素系统 生物合成 细胞凋亡 受体
作者
Hiroshi Tsugawa,Tomoaki Ishihara,Kota Ogasa,Seigo Iwanami,Aya Hori,Mikiko Takahashi,Yutaka Yamada,Aki Minoda,Makoto Arita
出处
期刊:Research Square - Research Square 被引量:1
标识
DOI:10.21203/rs.3.rs-2139359/v1
摘要

Abstract Understanding the molecular mechanisms associated with aging is important to improve the longevity of healthy individuals. Herein, we performed untargeted lipidomics to elucidate the relationship between aging and lipid metabolism in 13 mouse tissues at various life stages (2, 12, 19, and 24 months), in which sex and microbiome dependencies (specific pathogen free/germ free) were investigated. By analyzing 2,817 unique molecular profile data of 121 lipid subclasses, we characterized the common and tissue-specific lipidome changes associated with aging. For example, bis(monoacylglycerol)phosphate containing polyunsaturated fatty acids was enriched in various organs during aging, while other phospholipids containing saturated and monounsaturated fatty acids were decreased. In addition, we discovered an age-dependent increase of sulfonolipid (SL), which is biosynthesized in Alistipes and Odoribacter genera. SL molecules were absent in germ-free mice. Furthermore, the molecules appeared to be translocated from the intestinal lumen to various tissues such as the liver, kidney, and spleen. In the kidney, the associations of glycolipids such as galactosyl ceramides (GalCer), galabinosyl ceramides (Gal2Cer), trihexosyl ceramides (Hex3Cer), and mono and digalactosyl diacylglycerols were found in male mice, in which two lipid classes Gal2Cer and Hex3Cer were significantly enriched in aged mice. Integrated analysis of the kidney transcriptome revealed uridine diphosphate galactosyltransferase UGT8a, alkylglycerone phosphate synthase, and fatty acyl-CoA reductase 1 as potential enzymes responsible for male-specific glycolipid biosynthesis in vivo, which would be relevant to sex dependency in kidney diseases. Our lipidome results will become an important resource, led to the understanding of the molecular mechanisms underlying cellular senescence and age-related diseases.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
淡淡月饼完成签到,获得积分10
刚刚
刚刚
超帅无色完成签到,获得积分20
1秒前
snow完成签到 ,获得积分10
2秒前
5秒前
dream完成签到 ,获得积分10
7秒前
唐唐发布了新的文献求助10
7秒前
史克珍香完成签到 ,获得积分10
13秒前
晓风完成签到,获得积分10
16秒前
CR完成签到 ,获得积分10
17秒前
mammer应助超帅无色采纳,获得10
18秒前
科研通AI2S应助科研通管家采纳,获得10
18秒前
所所应助科研通管家采纳,获得10
19秒前
Owen应助科研通管家采纳,获得10
19秒前
19秒前
lilylwy完成签到 ,获得积分0
19秒前
li完成签到 ,获得积分10
19秒前
可爱的函函应助唐唐采纳,获得10
24秒前
小石头完成签到,获得积分10
26秒前
量子星尘发布了新的文献求助10
30秒前
xiaoxiaoxingchen完成签到 ,获得积分10
30秒前
laohu完成签到,获得积分10
31秒前
风格完成签到,获得积分10
31秒前
大橙子发布了新的文献求助150
33秒前
八点必起完成签到,获得积分10
34秒前
sduweiyu完成签到 ,获得积分10
35秒前
hyf完成签到 ,获得积分10
36秒前
aldehyde应助芊芊要发SCI采纳,获得10
37秒前
Twinkle完成签到,获得积分10
39秒前
Eureka完成签到,获得积分10
41秒前
45秒前
浮熙完成签到 ,获得积分10
52秒前
笔芯完成签到,获得积分10
55秒前
看文献完成签到,获得积分0
57秒前
爱与感谢完成签到 ,获得积分10
59秒前
华仔应助大橙子采纳,获得10
1分钟前
小帅完成签到,获得积分10
1分钟前
man完成签到 ,获得积分10
1分钟前
biofresh完成签到,获得积分10
1分钟前
平凡完成签到,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022