溶血酶-
信号转导
化学
计算生物学
受体
脂质代谢
细胞信号
神经科学
细胞生物学
生物
生物化学
计算机科学
闪烁体
电信
探测器
作者
Arnab Chakraborty,Siddhesh S. Kamat
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2024-04-12
卷期号:124 (9): 5470-5504
被引量:1
标识
DOI:10.1021/acs.chemrev.3c00701
摘要
Lysophosphatidylserine (lyso-PS) has emerged as yet another important signaling lysophospholipid in mammals, and deregulation in its metabolism has been directly linked to an array of human autoimmune and neurological disorders. It has an indispensable role in several biological processes in humans, and therefore, cellular concentrations of lyso-PS are tightly regulated to ensure optimal signaling and functioning in physiological settings. Given its biological importance, the past two decades have seen an explosion in the available literature toward our understanding of diverse aspects of lyso-PS metabolism and signaling and its association with human diseases. In this Review, we aim to comprehensively summarize different aspects of lyso-PS, such as its structure, biodistribution, chemical synthesis, and SAR studies with some synthetic analogs. From a biochemical perspective, we provide an exhaustive coverage of the diverse biological activities modulated by lyso-PSs, such as its metabolism and the receptors that respond to them in humans. We also briefly discuss the human diseases associated with aberrant lyso-PS metabolism and signaling and posit some future directions that may advance our understanding of lyso-PS-mediated mammalian physiology.
科研通智能强力驱动
Strongly Powered by AbleSci AI