高甘油三酯血症
安慰剂
载脂蛋白B
内分泌学
随机化
医学
内科学
脂蛋白
胃肠病学
随机对照试验
甘油三酯
胆固醇
替代医学
病理
作者
Brian A. Bergmark,Nicholas Marston,Thomas A Prohaska,Veronica J. Alexander,André Zimerman,Filipe A. Moura,Sabina A. Murphy,Erica L. Goodrich,S. M. Zhang,Daniel Gaudet,Ewa Karwatowska‐Prokopczuk,Sotirios Tsimikas,Robert P. Giugliano,Marc S. Sabatine
标识
DOI：10.1056/nejmoa2402309
摘要
Reducing the levels of triglycerides and triglyceride-rich lipoproteins remains an unmet clinical need. Olezarsen is an antisense oligonucleotide targeting messenger RNA for apolipoprotein C-III (APOC3), a genetically validated target for triglyceride lowering.
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