小胶质细胞
神经退行性变
神经科学
神经保护
神经炎症
生物
阿尔茨海默病
疾病
特雷姆2
β淀粉样蛋白
炎症
医学
免疫学
病理
作者
Izabela Lepiarz‐Raba,Taufik Hidayat,Anthony J. Hannan,Ali Jawaid
标识
DOI:10.1080/17460441.2024.2335210
摘要
Introduction Microglia, the primary immune cells in the brain, play multifaceted roles in Alzheimer's disease (AD). Microglia can potentially mitigate the pathological progression of AD by clearing amyloid beta (Aβ) deposits in the brain and through neurotrophic support. In contrast, disproportionate activation of microglial pro-inflammatory pathways, as well as excessive elimination of healthy synapses, can exacerbate neurodegeneration in AD. The challenge, therefore, lies in discerning the precise regulation of the contrasting microglial properties to harness their therapeutic potential in AD.
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