光动力疗法
体内
医学
金黄色葡萄球菌
铜绿假单胞菌
药物输送
伤口愈合
血管生成
再生(生物学)
荧光寿命成像显微镜
细菌
荧光
药理学
癌症研究
微生物学
免疫学
细胞生物学
化学
生物
遗传学
有机化学
物理
生物技术
量子力学
作者
Xiaoxue Li,Wei Wang,Qiuxia Gao,Shanshan Lai,Yan Liu,Sitong Zhou,Yan Yan,Jie Zhang,Huanhuan Wang,Jiamei Wang,Yi Feng,Ronghua Yang,Jianyu Su,Bin Li,Yuhui Liao
摘要
Abstract Infected burn wounds are characterized by persistent drug‐resistant bacterial infection coupled with an inflammatory response, impeding the wound‐healing process. In this study, an intelligent nanoparticle system (CCM+TTD@ZIF‐8 NPs) was prepared using curcumin (CCM), an aggregation‐induced emission luminogens (TTD), and ZIF‐8 for infection‐induced wound healing. The CCM+TTD@ZIF‐8 NPs showed multiple functions, including bacteria targeting, fluorescence imaging and pH response‐guided photodynamic therapy (PDT), and anti‐inflammatory. The positive charges of ZIF‐8 NPs allowed the targeting of drug‐resistant bacteria in infected wounds, thereby realizing fluorescence imaging of bacteria by emitting red fluorescence at the infected site upon blue light irradiation. The pH‐responsive characteristics of the CCM+TTD@ZIF‐8 NPs also enabled controllable CCM release onto the infected wound site, thereby promoting the specific accumulation of ROS at the infected site, with outstanding bactericidal efficacy against drug‐resistant Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) strains in vitro/in vivo. Additionally, due to the excellent bactericidal effect and anti‐inflammatory properties of CCM+TTD@ZIF‐8 NPs combined with blue light irradiation, the regeneration of epidermal tissue, angiogenesis, and collagen deposition was achieved, accelerating the healing process of infected burn wounds. Therefore, this CCM+TTD@ZIF‐8 NPs with multifunctional properties provides great potential for infected burn wound healing.
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