水解
食品科学
中国人口
人口
母乳
牛奶蛋白
过敏
牛奶过敏
牛奶过敏
水解蛋白
化学
医学
免疫学
食物过敏
生物化学
基因型
基因
环境卫生
作者
Sun Li-juan,Shiwen Han,Sufang Duan,Like Mao,Fang Li,Zhenhua Tu,Huilian Che
标识
DOI:10.1002/mnfr.202300909
摘要
Scope In cases where breast milk is unavailable or inadequate, hydrolyzed infant formula is recommended as the primary alternative. The aim of this study is to assess and compare the allergenicity of two partially hydrolyzed whey‐based formulas (PHF‐Ws) using serum samples from patients with cow's milk allergy (CMA). Methods and results LC‐MS/MS technology is used to investigate the peptide distribution in both samples. The immunoreactivity of two PHF‐Ws in 27 serum samples from 50 Chinese infants (02 years) with CMA is analyzed. The results demonstrate that even with a similar a degree of hydrolysis (DH), primary protein sources, peptides with molecular weights <5 kDa, and differences in the number of residual allergenic epitopes in the hydrolyzed peptide segments can lead to varying immune responses. Conclusion The two PHF‐Ws have notably high intolerance rates, exceeding 10% among infants with CMA. Therefore, suggesting that PHF‐Ws may not be suitable for infants and children with CMA in China.
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