An Unusual Duodenal Finding

十二指肠球 十二指肠 医学 食管胃十二指肠镜检查 小凹细胞 胃肠病学 内科学 胃息肉 病理 内窥镜检查 胃粘膜
作者
Kaitlyn Estes,Deepti Dhall,Frederick Weber
出处
期刊:Gastroenterology [Elsevier]
卷期号:164 (2): 194-195
标识
DOI:10.1053/j.gastro.2022.07.074
摘要

Question: A 72-year-old woman with a medical history of gastroesophageal reflux disease, obesity, acquired hypothyroidism, diabetes mellitus, hypertension, and diverticulosis presented with proton pump inhibitor–refractory dyspepsia. Esophagogastroduodenoscopy demonstrated a normal esophagus and stomach, but an unusual 20 × 18 mm glandular Paris IIa lesion was found in the duodenal bulb with a normal second portion of the duodenum. Endoscopic and histologic findings are shown in Figures A and B. What was the most likely diagnosis? Look on page 195 for the answer and see the Gastroenterology website (www.gastrojournal.org) for more information on submitting to Gastro Curbside Consult. Gastric heterotopia (GH) is a rare congenital condition where gastric tissue is found at a location outside the stomach. It may be found anywhere in the GI tract from mouth to anus and is found in the duodenal bulb in 0.5%-2% of individuals, where it most commonly appears as single or multiple asymptomatic polypoid lesions.1Khan S. Niaz S. Khan M. et al.A case of heterotopic gastric tissue in duodenal bulb: an interesting endoscopic finding.Cureus. 2022; 14e24271Google Scholar Large lesions may ulcerate (secondary to acid secretion), bleed, intussuscept, or obstruct, but that is uncommon. Histologically, GH shows aggregates of oxyntic glands composed of chief and parietal cells, and the overlying surface often exhibits gastric foveolar mucinous epithelium (apical mucin cap),2Maione F. Chini A. Gennarelli N. et al.Endoscopic resection of a large polypoid gastric heterotopia of duodenum: a case report.Clin Case Rep. 2021; 9e04633Crossref Google Scholar as demonstrated in the left portion of Figure B. The right portion of Figure B demonstrates normal duodenal mucosa (villi lined by goblet cells, absorptive epithelium, and rare Brunner’s glands). It is important to distinguish GH from the more common acquired condition gastric metaplasia (GM). GM involves the villous surface epithelium of the duodenum, and the metaplastic cells contain small apical vacuoles, similar to gastric foveolar cells, also known as gastric foveolar metaplasia. GM is a reactive process, often associated with duodenal mucosal injury/inflammation, which may or may not be due to Helicobacter pylori (HP) infection. In contrast, GH is not associated with HP, it shows normal duodenal mucosa in the background, and has an association with fundic gland polyps, possibly due to an indirect association through PPI therapy enhancing the endoscopic prominence of GH.3Narang Natasha et al.Gastric tissue in the duodenal bulb: heterotopia or metaplasia?.Am J Gastroenterol. 2020; 115: S1446Crossref Google Scholar Importantly, oxyntic glands characteristic of GH are not identified in GM. Finally, GH often manifests as nodular mucosa endoscopically, whereas GM is detected microscopically. It has been suggested that GH may have neoplastic potential.3Narang Natasha et al.Gastric tissue in the duodenal bulb: heterotopia or metaplasia?.Am J Gastroenterol. 2020; 115: S1446Crossref Google Scholar Therefore, accurate endoscopic and pathologic identification may be important, although it will require further investigation to determine if endoscopic surveillance is warranted.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Beta发布了新的文献求助10
4秒前
和谐的果汁完成签到 ,获得积分10
13秒前
Zoe完成签到 ,获得积分10
25秒前
康复小白完成签到 ,获得积分10
26秒前
灰鸽舞完成签到 ,获得积分10
26秒前
Emma完成签到,获得积分10
29秒前
Willy完成签到 ,获得积分10
32秒前
吃小孩的妖怪完成签到 ,获得积分10
34秒前
why完成签到,获得积分10
41秒前
碧蓝雁风完成签到 ,获得积分10
43秒前
赧赧完成签到 ,获得积分10
44秒前
sara完成签到,获得积分10
46秒前
mrwang完成签到 ,获得积分10
46秒前
wbscz完成签到 ,获得积分10
48秒前
轩辕剑身完成签到,获得积分0
48秒前
阿托伐他汀完成签到 ,获得积分10
49秒前
xue112完成签到 ,获得积分10
56秒前
嘿嘿完成签到 ,获得积分10
56秒前
onevip完成签到,获得积分10
58秒前
1分钟前
困困困完成签到 ,获得积分10
1分钟前
科研小郭完成签到,获得积分10
1分钟前
khaosyi完成签到 ,获得积分10
1分钟前
苏子轩完成签到 ,获得积分10
1分钟前
ghost完成签到 ,获得积分10
1分钟前
迢迢笙箫应助齐齐采纳,获得10
1分钟前
科研小南瓜完成签到 ,获得积分10
1分钟前
Jack完成签到 ,获得积分10
1分钟前
铁妹儿完成签到 ,获得积分10
1分钟前
SuMX完成签到 ,获得积分10
1分钟前
hcdb完成签到,获得积分10
1分钟前
gaoxiaogao完成签到 ,获得积分10
1分钟前
花朝唯完成签到 ,获得积分10
1分钟前
wx1完成签到 ,获得积分0
1分钟前
妖哥完成签到,获得积分10
1分钟前
烟酒不离生完成签到 ,获得积分10
1分钟前
chenying完成签到 ,获得积分0
1分钟前
haochi完成签到,获得积分10
2分钟前
AAAAA完成签到 ,获得积分10
2分钟前
ninomae完成签到 ,获得积分10
2分钟前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 400
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3155031
求助须知:如何正确求助?哪些是违规求助? 2805746
关于积分的说明 7865913
捐赠科研通 2464038
什么是DOI,文献DOI怎么找? 1311698
科研通“疑难数据库(出版商)”最低求助积分说明 629728
版权声明 601862