失调
类风湿性关节炎
医学
免疫学
微生物群
自身免疫
疾病
免疫系统
自身免疫性疾病
关节炎
肠道菌群
发病机制
炎症
生物信息学
生物
内科学
抗体
作者
Malavikalakshmi Attur,Jose U. Scher,Steven B. Abramson,Mukundan Attur
出处
期刊:Cells
[MDPI AG]
日期:2022-08-05
卷期号:11 (15): 2436-2436
被引量:32
标识
DOI:10.3390/cells11152436
摘要
Rheumatoid arthritis is a chronic systemic immune-mediated disease caused by genetic and environmental factors. It is often characterized by the generation of autoantibodies that lead to synovial inflammation and eventual multi-joint destruction. A growing number of studies have shown significant differences in the gut microbiota composition of rheumatoid arthritis (RA) patients compared to healthy controls. Environmental factors, and changes in diet and nutrition are thought to play a role in developing this dysbiosis. This review aims to summarize the current knowledge of intestinal dysbiosis, the role of nutritional factors, and its implications in the pathogenesis of rheumatoid arthritis and autoimmunity. The future direction focuses on developing microbiome manipulation therapeutics for RA disease management.
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