Anticancer Activity of Noni Fruit (Morinda citrifolia) Extracts Against Human Hepatocellular Carcinoma Cell Line (HepG-2) and its Appototic Mechanism

Morinda citrifolia L. (Noni) fruits have been used for thousands of years for the treatment of many health problems including cancer, cold, diabetes, flu, hypertension, and pain. Plant extracts have reported for several therapeutic benefits, but extraction of individual compound from the extract often exhibits limited clinical utility as the synergistic effect of various natural ingredients gets lost. They generally constitute polyphenols and flavonoids. Studies have suggested that these phytochemicals, especially polyphenols, display high antioxidant properties, which help to reduce the risk of degenerative diseases, such as cancer and cardiovascular diseases. Several in vitro and in vivo studies have shown that Noni fruits have antioxidant, anti-inflammatory, anti-dementia, liver-protective, anticancer, analgesic, and immunomodulatory effects. In this study M. citrifolia fruit extracts were evaluated for its phytochemical profiling and anticancer activity. The extracts exhibited potential anticancer activity thus the methanolic extract of M. citrifolia can be used as novel anticancer agent in future.