Association between gut microbiota and post-stroke depression in Chinese population: A meta-analysis

萧条(经济学) 肠道菌群 荟萃分析 冲程(发动机) 脑卒中后抑郁 医学 联想(心理学) 人口 心理学 生物 内科学 环境卫生 免疫学 心理治疗师 工程类 宏观经济学 经济 治疗组和对照组 机械工程
作者
Fang Luo,Chengbing Fang
出处
期刊:Heliyon [Elsevier BV]
卷期号:8 (12): e12605-e12605 被引量:4
标识
DOI:10.1016/j.heliyon.2022.e12605
摘要

BackgroundPost-stroke depression (PSD) is a common neuropsychological complication after a stroke with a range of poor outcomes. Evidence of gut microbiota disorder for PSD has recently accumulated. This study aimed to systematically evaluate the association between PSD and gut microbiota.MethodsWe searched PubMed, Web of Science, Embase, and VIP, CNKI, Wangfang without language restrictions for eligible studies and performed a meta-analysis and systematic review to assess the pooled differences in gut microbiota compositions between PSD and healthy individuals.ResultsWe included nine eligible studies reporting the differences in the intestinal microbiome between PSD and healthy control. The pooled results demonstrated that the sequencing depth index (Good's coverage), richness indexes (Chao1 and ACE), evenness, and alpha diversity (Shannon and Simpson) were not significantly changed in PSD patients as compared to healthy controls. The observed species (operational taxonomic unit, OUT) in PSD was significantly higher than that in healthy individuals (SMD, 1.86, 95%CI: 1.47 to 2.25). Furthermore, we observed significant differences between PSD and healthy individuals at the phylum level. The pooled estimation of relative abundance of Proteobacteria (SMD, 0.37, 95%CI: 0.19 to 0.55), Bacteroidetes (SMD, 1.87, 95%CI: 1.25 to 2.48), and Fusobacteria (SMD, 1.06, 95%CI: 0.76 to 1.37) in patients with PSD significantly was increased as compared to controls, while the pooled relative abundance of Firmicutes (SMD, -0.84, 95%CI: -1.21 to -0.47) was significantly decreased in PSD as compared to healthy controls. Moreover, significant differences in intestinal microbiota were observed between PSD patients and healthy controls at the family and genus levels.ConclusionsThis meta-analysis indicates a significant alteration of observed species and microbiota composition at the phylum, family and genus levels in PSD as compared to healthy individuals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
幽默的素阴完成签到 ,获得积分10
1秒前
小小鱼完成签到 ,获得积分10
8秒前
8秒前
甜美砖家完成签到 ,获得积分10
10秒前
superspace完成签到,获得积分10
11秒前
nn发布了新的文献求助10
13秒前
求助完成签到,获得积分10
14秒前
15秒前
翁雁丝完成签到 ,获得积分10
22秒前
郭义敏完成签到,获得积分0
22秒前
gyf完成签到,获得积分10
25秒前
李保龙完成签到 ,获得积分10
26秒前
30秒前
LJJ完成签到 ,获得积分10
31秒前
量子星尘发布了新的文献求助10
34秒前
阿姨洗铁路完成签到 ,获得积分10
39秒前
抹不掉的记忆完成签到,获得积分10
41秒前
41秒前
余杭村王小虎完成签到,获得积分10
42秒前
韭黄完成签到,获得积分20
46秒前
jeffrey完成签到,获得积分10
46秒前
Rondab应助机灵枕头采纳,获得10
52秒前
佳无夜完成签到,获得积分10
57秒前
摆哥完成签到,获得积分10
1分钟前
66完成签到,获得积分10
1分钟前
zlqq完成签到 ,获得积分10
1分钟前
Hardskills发布了新的文献求助10
1分钟前
1分钟前
之_ZH完成签到 ,获得积分10
1分钟前
gds2021完成签到 ,获得积分10
1分钟前
你好呀嘻嘻完成签到 ,获得积分10
1分钟前
梅特卡夫完成签到,获得积分10
1分钟前
熊雅完成签到,获得积分10
1分钟前
1分钟前
睡到自然醒完成签到 ,获得积分10
1分钟前
cis2014完成签到,获得积分10
1分钟前
独特的大有完成签到 ,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
1分钟前
xingyi完成签到,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038112
求助须知:如何正确求助?哪些是违规求助? 3575788
关于积分的说明 11373801
捐赠科研通 3305604
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022