A targeted liposome nanoparticles for the combined treatment of melanoma with photothermal therapy and chemotherapy

Currently, the therapeutic tools and therapeutic effects of melanoma are very limited, therefore, this paper designed a liposome encapsulated with indocyanine green and vincristine, modified by transferrin and polyethylene glycol, with the aim of improving new ideas for tumor treatment. This paper attempted to prepare nanoparticles by thin film evaporation ultrasonic dispersion method, and experiments were conducted on the morphology, particle size, zeta potential, drug loading rate, encapsulation rate, photothermal effect, drug in vitro release, cellular uptake and cytotoxicity of the prepared nanoparticles. The experimental results verified the good performance of the nanoparticles designed in this paper for the combined treatment of melanoma.