An exploratory study of the gut microbiota in major depression with anxious distress

UniFrac公司 焦虑 重性抑郁障碍 苦恼 萧条(经济学) 心理学 临床心理学 心理健康 多样性指数 微生物群 α多样性 基因组 广泛性焦虑症 生物 精神科 心情 物种丰富度 生态学 生物信息学 遗传学 16S核糖体RNA 基因 宏观经济学 经济
作者
Gabrielle Ritchie,Esben Strodl,Sophie Parham,Matthew Bambling,Susanna Cramb,Luis Vitetta
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:320: 595-604 被引量:15
标识
DOI:10.1016/j.jad.2022.10.001
摘要

To explore differences in the diversity and composition of the gut microbiome between major depressive disorder (MDD) with and without anxious distress. The study comprised 117 participants (79 female, 36 male, 2 other, mean age 38.2 ± 13.4 years) with a current major depressive episode (MDE) with (n = 63) and without (n = 54) the anxious distress specifier. A clinical psychologist administered the structured clinical interview for the DSM-5-RV to confirm a diagnosis of depression. Participants provided stool samples which were immediately frozen and stored at −80 °C. These samples were analysed using the Illumina 16S Metagenomics sequencing protocol in which the sequencing primers target the V3 and V4 regions of the 16S rRNA gene. Participants also completed mental health questionnaires to assess severity of depression (BDI-II), generalized anxiety (GAD-7), and stress (PSS). There were no significant group differences in α-diversity (Shannon's diversity Index; Simpson Index), richness (ACE; Chao1), (Pielou's) evenness, or beta diversity (Bray-Curtis dissimilarity index and weighted UniFrac distance) of gut bacteria. Significant group differences in the relative abundance of gut microbiota however were observed at each taxonomical level, including across 15 genera and 18 species. This was an exploratory study that needs to be replicated across larger samples and compared with a healthy control group. The research contributes to knowledge of the depressive gut microbial profile unique to the anxious distress subtype of MDD.
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