动员
花生四烯酸
病理
脂质过氧化
医学
小胶质细胞
神经科学
化学
生物
氧化应激
免疫学
内科学
生物化学
炎症
政治学
酶
法学
作者
Da Lin,Andrew K. Gold,Sarah J. Kaye,Jeffrey R. Atkinson,Marcus J. Tol,Andrew Sas,Benjamin M. Segal,Peter Tontonoz,Jiangjiang Zhu,Jie Gao
标识
DOI:10.1523/jneurosci.0202-24.2024
摘要
Aberrant increase of arachidonic acid (ARA) has long been implicated in the pathology of Alzheimer's disease (AD), while the underlying causal mechanism remains unclear. In this study, we revealed a link between ARA mobilization and microglial dysfunction in Aβ pathology. Lipidomic analysis of primary microglia from App
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