An innovative C–H arylation strategy to make chiral phosphines

Despite the significant advancements in catalytic P(III)-directed C−H activation reactions, the higher dissociation energy and stronger metal coordination of P(III) directing groups present substantial challenges for catalytic asymmetric C−H activation. In our work, we have showcased that by utilizing chiral phosphoramidite ligands, it is feasible to synthesize planar chiral ferrocenyl phosphines. This was accomplished through a pivotal palladium-catalyzed enantioselective P(III)-directed C−H arylation step.