电化学
化学
芳香性
分子
组合化学
还原(数学)
有机化学
电极
物理化学
几何学
数学
作者
Hao Li,Yan Li,Jiaye Chen,Lijun Lu,Pengjie Wang,Jingcheng Hu,Rui Ma,Yiming Gao,Hong Yi,Wu Li,Aiwen Lei
标识
DOI:10.1002/anie.202407392
摘要
Abstract The reduction of aromatic compounds constitutes a fundamental and ongoing area of investigation. The selective reduction of polycyclic aromatic compounds to give either fully or partially reduced products remains a challenge, especially in applications to complex molecules at scale. Herein, we present a selective electrochemical hydrogenation of polycyclic arenes conducted under mild conditions. A noteworthy achievement of this approach is the ability to finely control both the complete and partial reduction of specific aromatic rings within polycyclic arenes by judiciously varying the reaction solvents. Mechanistic investigations elucidate the pivotal role played by in situ proton generation and interface regulation in governing reaction selectivity. The reductive electrochemical conditions show a very high level of functional‐group tolerance. Furthermore, this methodology represents an easily scalable reduction (demonstrated by the reduction of 1 kg scale starting material) using electrochemical flow chemistry to give key intermediates for the synthesis of specific drugs.
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