戊二醛
气凝胶
聚乙烯醇
乙烯醇
壳聚糖
阳离子聚合
化学工程
材料科学
X射线光电子能谱
聚合物
高分子化学
化学
纳米技术
有机化学
工程类
作者
Dorota Lachowicz,Angelika Kmita,Roma Wirecka,Katarzyna Berent,Michał Szuwarzyński,Szczepan Zapotoczny,Anna Pajdak,Grzegorz Cios,Natalia Mazur-Panasiuk,Krzysztof Pyrć,Andrzej Bernasik
标识
DOI:10.1016/j.carbpol.2023.120756
摘要
In this study, we developed a new filtering bioaerogel based on linear polyvinyl alcohol (PVA) and the cationic derivative of chitosan (N-[(2-hydroxy-3-trimethylamine) propyl] chitosan chloride, HTCC) with a potential antiviral application. A strong intermolecular network architecture was formed thanks to the introduction of linear PVA chains, which can efficiently interpenetrate the glutaraldehyde(GA)-crosslinked HTCC chains. The morphology of the obtained structures was examined using scanning electron microscopy (SEM) and atomic force microscopy (AFM). The aerogels and modified polymers' elemental composition (including the chemical environment) was determined using X-ray photoelectron spectroscopy (XPS). New aerogels with more than twice as much developed micro- and mesopore space and BET-specific surface area were obtained concerning the starting sample chitosan aerogel crosslinked by glutaraldehyde (Chit/GA). The results obtained from the XPS analysis showed the presence of cationic 3-trimethylammonium groups on the surface of the aerogel, which can interact with viral capsid proteins. No cytotoxic effect of HTCC/GA/PVA aerogel was also observed on fibroblast cells of the NIH3T3 line. Furthermore, the HTCC/GA/PVA aerogel has been shown that efficiently traps mouse hepatitis virus (MHV) from suspension. The presented concept of aerogel filters for virus capture based on modified chitosan and polyvinyl alcohol has a high application potential.
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