乳腺癌
Wnt信号通路
抗药性
医学
中医药
药品
化疗
癌症
癌症研究
肿瘤科
药理学
内科学
信号转导
生物
病理
替代医学
微生物学
生物化学
作者
Xinlei Wu,Shen-Guo Lin,Yi-Wen Mao,Junxian Wu,Chen-Da Hu,Rui Lv,Hong-Dou Zeng,Minghao Zhang,Lizi Lin,Shanshan Ouyang,Yaxin Zhao
出处
期刊:Expert Reviews in Molecular Medicine
[Cambridge University Press]
日期:2023-01-01
卷期号:25
被引量:5
摘要
Abstract Breast cancer is a high-risk disease with a high mortality rate among women. Chemotherapy plays an important role in the treatment of breast cancer. However, chemotherapy eventually results in tumours that are resistant to drugs. In recent years, many studies have revealed that the activation of Wnt/ β -catenin signalling is crucial for the emergence and growth of breast tumours as well as the development of drug resistance. Additionally, drugs that target this pathway can reverse drug resistance in breast cancer therapy. Traditional Chinese medicine has the properties of multi-target and tenderness. Therefore, integrating traditional Chinese medicine and modern medicine into chemotherapy provides a new strategy for reversing the drug resistance of breast tumours. This paper mainly reviews the possible mechanism of Wnt/ β -catenin in promoting the process of breast tumour drug resistance, and the progress of alkaloids extracted from traditional Chinese medicine in the targeting of this pathway in order to reverse the drug resistance of breast cancer.
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