A ferroptosis-related gene in Helicobacter pylori infection, SOCS1, serves as a potential prognostic biomarker and corresponds with tumor immune infiltration in stomach adenocarcinoma: In silico approach

列线图 肿瘤科 细胞因子信号抑制因子1 生物标志物 免疫系统 内科学 医学 免疫疗法 幽门螺杆菌 癌症 癌症研究 生物 免疫学 生物化学 抑制器
作者
Ping Yan,Mingjing Cheng,Li Wang,Weidong Zhao
出处
期刊:International Immunopharmacology [Elsevier]
卷期号:119: 110263-110263 被引量:5
标识
DOI:10.1016/j.intimp.2023.110263
摘要

Helicobacter pylori (H. pylori) is a major risk factor for the stomach adenocarcinoma (STAD). This study aimed to investigate the potential role of a H. pylori infection-related gene, SOCS1, in STAD.Online available databases were analyzed to determine the expression, correlations with clinicopathologic parameters, patients' survival, and immunological characteristics of SOCS1 in TCGA-STAD or GEO datasets. Univariate and multivariate Cox regression analyses were used to determine independent risk factors, which were further integrated to establish a nomogram. A comparison of drug sensitivity was conducted for the chemotherapy responses between individuals with low- and high-SOCS1. Prediction of tumor response to checkpoint inhibitors was based on the tumor immunodeficiency and exclusion (TIDE) score.SOCS1 expression was significantly increased in both H. pylori-infected and STAD patients. Higher SOCS1 expression indicated an undesirable prognosis in STAD patients. SOCS1 upregulation was related to enhanced immune cell infiltrations and the upregulation of immune checkpoints in STAD patients. N stage, age and SOCS1 were identified as independent risk factors for higher mortality of STAD patients and confirmed using the nomogram. Drug sensitivity analyses demonstrated that high expression of SOCS1 in STAD patients could improve the sensitivity to chemotherapy. TIDE score showed that STAD patients with high SOCS1 expression would have superior response to immunotherapy.SOCS1 may act as a potential biomarker for uncovering the underlying mechanisms of gastric cancer. Increasing the activity of immunotherapy through ferroptosis-immunomodulation may be a viable strategy in STAD therapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
时尚雨兰完成签到,获得积分10
刚刚
圆圆完成签到,获得积分10
刚刚
徐橙橙完成签到,获得积分10
1秒前
Mt完成签到,获得积分10
2秒前
酷酷菲音完成签到,获得积分10
2秒前
落落大方完成签到,获得积分10
3秒前
3秒前
笑一笑完成签到 ,获得积分10
5秒前
朱诗源完成签到 ,获得积分10
5秒前
Singularity应助我有一只猫采纳,获得10
5秒前
义气小白菜完成签到 ,获得积分10
7秒前
左丘完成签到,获得积分10
8秒前
9秒前
Liang完成签到,获得积分10
9秒前
10秒前
科研野狗完成签到 ,获得积分10
12秒前
英姑应助书生采纳,获得10
12秒前
ltxinanjiao完成签到,获得积分10
14秒前
jonghuang发布了新的文献求助10
14秒前
JoaquinH完成签到,获得积分10
14秒前
15秒前
山野桃饼完成签到,获得积分10
15秒前
crucible发布了新的文献求助10
17秒前
科研通AI2S应助等后来呢采纳,获得10
17秒前
01259完成签到 ,获得积分10
18秒前
18秒前
星辰大海应助Candice采纳,获得10
19秒前
pigeonKimi完成签到,获得积分10
20秒前
AteeqBaloch完成签到,获得积分10
20秒前
wwz完成签到 ,获得积分10
20秒前
我不困完成签到,获得积分10
21秒前
稳重的蜡烛完成签到,获得积分10
22秒前
小北完成签到,获得积分20
22秒前
gyx完成签到,获得积分10
22秒前
南国完成签到,获得积分10
22秒前
jonghuang完成签到,获得积分10
23秒前
个性的大地完成签到,获得积分10
24秒前
24秒前
Hrentiken完成签到,获得积分10
25秒前
33完成签到 ,获得积分10
25秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Le dégorgement réflexe des Acridiens 800
Defense against predation 800
A Dissection Guide & Atlas to the Rabbit 600
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3134060
求助须知:如何正确求助?哪些是违规求助? 2784861
关于积分的说明 7769049
捐赠科研通 2440325
什么是DOI,文献DOI怎么找? 1297361
科研通“疑难数据库(出版商)”最低求助积分说明 624959
版权声明 600792